Carlo Francesco Nuvolone (Milan, 1608 or 1609 – Milan, 1661 or 1662) was an Italian painter of religious subjects and portraits who was active mainly in Lombardy. He became the leading painter in Lombardy in the mid-17th century, producing works on canvas as well as frescoes. Because his style was perceived as close to that of Guido Reni he was nicknamed il Guido della Lombardia (the Guido of Lombardy).

Carlo Francesco Nuvolone was born in Milan. His father Panfilo Nuvolone was a painter of frescoes and altarpieces, in a style still linked to late Mannerism, and of still lifes. Carlo Francesco had a brother called Giuseppe who also became a painter.

After working with his father, Carlo Francesco studied at the Accademia Ambr...